@article {Fischer2023,
	title = {Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics},
	journal = {Angewandte Chemie - International Edition},
	volume = {62},
	number = {43},
	year = {2023},
	note = {cited By 9},
	abstract = {The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50 \%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplasm selectivity, with approximately 5,000-, 8,000- and 50,000-fold more expression in the cancerous cells, respectively. The incorporation of the SARS-CoV-2 spike protein in the gene vector promotes specific recognition of the immune-evading hepatoma by the COVID-19-analogous immune response, which leads to cytotoxic and inflammatory activity, mediated by serum components taken from vaccinated or recovered COVID-19 patients, resulting in effective elimination of the hepatoma (>85 \% yield). {\textcopyright} 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.},
	doi = {10.1002/anie.202311590},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171435791\&doi=10.1002\%2fanie.202311590\&partnerID=40\&md5=7664a4e7c23b2a15db1adbdf3b3a441e},
	author = {Fischer, A. and Ehrlich, A. and Plotkin, Y. and Ouyang, Y. and Asulin, K. and Konstantinos, I. and Fan, C. and Nahmias, Y. and Willner, I.}
}
