@article {Kidambi2009657,
	title = {Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells},
	journal = {NeuroReport},
	volume = {20},
	number = {7},
	year = {2009},
	note = {cited By 8},
	pages = {657-662},
	abstract = {This study explored the effects of propofol on c-Fos and Egr-1 in neuroblastoma (N2A) cells. We demonstrate that propofol induced the expression of c-Fos and Egr-1 within 30 and 60min of exposure time. At 16.8μM concentration, propofol induced a 6 and 2.5-fold expression of c-Fos and Egr-1, respectively. However, at concentrations above 100μM, propofol failed to induce expression of c-Fos or Egr-1. Propofol-induced c-Fos and Egr-1 transcription was unaffected by bicuculline, a γ-aminobutyric acid-A receptor antagonist, but was abolished by PD98059, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor. Our study shows that clinically relevant concentrations of propofol induce c-Fos and Egr-1 expression through an extracellular signal-regulated kinase mediated and γ-aminobutyric acid-A independent pathway. {\textcopyright} 2009 Wolters Kluwer Health | Lippincott Williams \& Wilkins.},
	doi = {10.1097/WNR.0b013e328329a449},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-67049171035\&doi=10.1097\%2fWNR.0b013e328329a449\&partnerID=40\&md5=1e3405c2cf5efb41a094042f8802428b},
	author = {Kidambi, S. and Yarmush, J. and Fong, W. and Kamath, S. and Schianodicola, J. and Nahmias, Y.}
}
