@article {Benny2008799,
	title = {An orally delivered small-molecule formulation with antiangiogenic and anticancer activity},
	journal = {Nature Biotechnology},
	volume = {26},
	number = {7},
	year = {2008},
	note = {cited By 165},
	pages = {799-807},
	abstract = {Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum angiogenesis inhibitors. However, a major clinical limitation is its poor oral availability and short half-life, necessitating frequent, continuous parenteral administration. We have addressed these issues and report an oral formulation of TNP-470, named Lodamin. TNP-470 was conjugated to monomethoxy-polyethylene glycol-polylactic acid to form nanopolymeric micelles. This conjugate can be absorbed by the intestine and selectively accumulates in tumors. Lodamin significantly inhibits tumor growth, without causing neurological impairment in tumor-bearing mice. Using the oral route of administration, it first reaches the liver, making it especially efficient in preventing the development of liver metastasis in mice. We show that Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention. {\textcopyright} 2008 Nature Publishing Group.},
	doi = {10.1038/nbt1415},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-46949110744\&doi=10.1038\%2fnbt1415\&partnerID=40\&md5=d3addc42a73d156cb88910c105f1999c},
	author = {Benny, O. and Fainaru, O. and Adini, A. and Cassiola, F. and Bazinet, L. and Adini, I. and Pravda, E. and Nahmias, Y. and Koirala, S. and Corfas, G. and D{\textquoteright}Amato, R.J. and Folkman, J.}
}
