Our work involves creating advanced biological models that emulate critical aspects of human physiology and disease. Recently, we showed that anisotropic stress induced by vascularization produces multi-chambered cardiac organoids that contain a pericardium, endocardium, and pacemakers' clusters. Our work went on to show that in humans and pigs, electrical activity is synchronized with mitochondrial respiration. Disruption of synchronizing Ca2+ fluxes caused arrythmia (Ghosheh et al., Nature Biomed., 2023)​.

 

 

In another study, we developed a robotic screening platform for human glioblastoma organoids. Patient-derived vascularized glioblastoma organoids recreated the complex niches. Single cell analysis showed marked contribution of the multiple stem cell populations observed in patients. Sensors embedded in the glioblastoma organoids revealed a group of slow acting drugs with higher specificity to cancer stem cells.